~42 mi · 50 minutes

I-40 E to US-441 S through Sevierville and Pigeon Forge

~85 mi · 1 hour 30 minutes

I-40 W to the gateway towns, or the scenic US-441 over Newfound Gap via Cherokee

~95 mi · 1 hour 45 minutes

I-26 W to I-40 W, then US-441 S

~115 mi · 2 hours

US-25 N to I-26/I-40, or via Asheville and Newfound Gap

~150 mi · 2 hours 45 minutes

I-75 N to I-40 E to the Sevierville exits

~200 mi · 3 hours 30 minutes

I-40 W through Asheville to the gateway towns

~200 mi · 3 hours 15 minutes

I-40 W through Asheville to the gateway towns

~210 mi · 3 hours 30 minutes

I-75 N to I-40 E (or the scenic US-441 through Cherokee and over Newfound Gap)

~215 mi · 3 hours 30 minutes

I-40 E almost the entire way to the Sevierville/Pigeon Forge exits

~225 mi · 3 hours 45 minutes

I-75 S through Knoxville, then I-40 E and US-441 S

~240 mi · 4 hours

I-26 W to Asheville, then I-40 W to the gateway towns

~250 mi · 4 hours

US-72 E to Chattanooga, then I-75 N and I-40 E

~265 mi · 4 hours

I-65 S to Nashville, then I-40 E across to the gateway towns

~285 mi · 4 hours 30 minutes

I-40 W the entire way through Asheville

~290 mi · 4 hours 30 minutes

I-65 S to I-40 E (or I-75 S through Lexington and Knoxville)

~320 mi · 5 hours

I-75 S to Knoxville, then I-40 E and US-441 S

~320 mi · 5 hours

I-59 N to Chattanooga, then I-75 N and I-40 E

~360 mi · 5 hours 30 minutes

I-71 S to Cincinnati, then I-75 S and I-40 E

~385 mi · 6 hours

I-65 S to Louisville, then I-40 E through Knoxville

~415 mi · 6 hours 15 minutes

I-40 E straight across Tennessee through Nashville and Knoxville